Cerebral malaria ELQ-300

I used PubMed, searching for evidences about this new drug, ELQ-300. With the PICO metod there was no results if i used toomany key words, so i made a first research only with (malaria) AND (ELQ-300), and i had 8 results; if i tried to limit the research only for R.T.C. or review there was no results. The first abstract, the most recent(1), evalueted 4 trials in which ELQ-300 was used in mice for a lung-acting injectable chemoprotectio, and they was promising for human's durable protection.

Another article studied an efficient combination of Atovaquone and ELQ-300, inibiting two site of  in mytochondria's cytocrhome(2).

When i added in the search box the key word (safety), pubmed underlined an interesting study that shows as a low dose of ELQ-300 was efficacy too to protect from P.Falciparum(3)

(1) ELQ-331 as a prototype for extremely durable chemoprotection against malaria.

Smilkstein MJ, Pou S, Krollenbrock A, Bleyle LA, Dodean RA, Frueh L, Hinrichs DJ, Li Y, Martinson T, Munar MY, Winter RW, Bruzual I, Whiteside S, Nilsen A, Koop DR, Kelly JX, Kappe SHI, Wilder BK, Riscoe MK.

Malar J. 2019 Aug 27;18(1):291. doi: 10.1186/s12936-019-2921-9.

(2) Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria.

Stickles AM, Smilkstein MJ, Morrisey JM, Li Y, Forquer IP, Kelly JX, Pou S, Winter RW, Nilsen A, Vaidya AB, Riscoe MK.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4853-9. doi: 10.1128/AAC.00791-16. Print 2016 Aug

(3) Antimicrob Agents Chemother. 2015 Sep;59(9):5555-60. doi: 10.1128/AAC.01183-15. Epub 2015 Jun 29.

ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.

Miley GP1, Pou S1, Winter R1, Nilsen A1, Li Y1, Kelly JX1, Stickles AM2, Mather MW3, Forquer IP1, Pershing AM3, White K4, Shackleford D4, Saunders J4, Chen G4, Ting LM5, Kim K5, Zakharov LN6, Donini C7, Burrows JN7, Vaidya AB8, Charman SA9, Riscoe MK10