Topic outline

  • Lectures n. 14 and 15 and 17: mon 23, fri 27 of april  and 4 of may 2018.

    ENTROPY RULES

    Structures as free energy minimisers PBoC 5.5

    The marginal stability of protein structures as a compensation between enthalpy and entropy

    Mechanical forces/entropic forces

    Stabilisation against solubility vs misfolding and aggregation (Positive and negative design)

    Entropy and hydrophobicity (PBoC 5.5.1)

    The hydrophobic effect as an entropic force.

    The residual entropy of ice (Pauling model 1935)