Section outline
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Lecture N. 5 TUE OCT 5 2023 room 8 12am-2pm
biological physics/physical biology; biologically inspired physics/biophysics
evolutionary distances (slides CB_22_23_L4.pdf, integrate with further self-study)
genomes and the genetic code: Central dogma of molecular biology, informational biomolecules: nucleic acids & proteins: peptide bonds formation and planarity, protein synthesis on the ribosome, genetic code and its degeneration (codon bias) (HA 2.2, 2.3)
what is darwinian evolution (HA 3.1,3.2, 3.3 (mutations), 3.4 (coalescence) 3.6 (neutral evolution and adaptation, codon bias))
the space of biological sequences as the archive of evolution (molecules as documents of evolutionary history, see: ZuckerkandlPauling1965
molecular evolution of nucleotide sequences
essential genes, homologous/paralogous genes
evolutionary distances d vs. sequence identity D
sequence/structure/dynamics/function
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Students mustMark as done
Find here materials to complement the track of this lectureN.4: In particular the introductory chapter of Weinberg's treatise on Cancer and the interesting paper Physics is life by Goldenfeld and Woese.
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