All professional nurses, regardless of educational preparation, need to be able to practice evidence-based nursing. Foremost, this begins with the ability to ask searchable and answerable clinical questions—in other words, to question one’s practice. In order to do this, the following skills and characteristics need to be developed: constant curiosity, knowledge of basic research principles, knowledge of and experience in how to ask relevant questions and the ability to search for and critique the evidence to answer these questions, the application of relevant evidence to practice, and the evaluation of its effectiveness.