Pathology and Pathophysiology (II)
- Oncology: Cell/Tissue phenotypic changes: metaplasia, dysplasia, anaplasia and precancerous lesions.
- Definition of cancer. Morphological and biochemical features of the neoplastic cell. Histogenetic classification
of tumors. Clinical criteria for the classification of tumors: grading and staging. Pathophysiology of replication
and of cell differentiation and growth factors. Physical, chemical, viral and hormonal cancerogenesis. Stages of
the neoplastic process: initiation, promotion and progression (invasion, metastasis, angiogenesis). Oncogenes
and their activation mechanisms. Tumor suppressor genes. Genomic instability. Heredityary tumors.
Immunity, inflammation and cancer. Biological basis of target antineoplastic therapy. - General Pathophysiology: Pathophysiology of metabolism (amino acids, purine and pyrimidine bases, lipids
and lipid disorders). - Pathophysiology of the Endocrine System: classes of hormones and receptors, secretion and transport.
- Pathophysiology of the thyroid gland: epithelial cells and parafollicular C cells, thyroid hormones, transporters
iodine and TPO. Pathogenesis of hypothyroidism and hyperthyroidism, papillary thyroid cancer, follicular,
medullary and anaplastic (MTC). - Pathophysiology of diabetes mellitus: endocrine pancreas, definitions and etiological classification: type 1
diabetes, type 2 diabetes, other types of diabetes and gestational diabetes: Pathophysiology of complications of
the diabetic patient. The gut hormones: the incretin hormones GLP-1 and GIP. Atherogenesis and
atherosclerosis. - General pathophysiology of blood, blood-forming organs and haemostasis.
- General pathophysiology of major systems: renal, respiratory, hepatic, cardiocirculatory systems; fluid and
electrolyte replacement; acid-base balance.
Suggested texbooks:
- Pathologic Basis of Disease. Robbins & Cotran. Eight Edition. Editor: W B Saunders Co, 2009
- Understanding pathophysiology. S. Huether, K. McCance. Elsevier, 2012
- Cells, Tissues and Disease. Principles of general pathology. G. Majno, I. Joris. Oxford University Press, 2004.
- Rubin’s Pathology. Clinicopathologic foundation of medicine. Rubin & Straier. Lippincott Raven; 6 Har/Psc, ed. ,
2011.
- Docente: GIANLUCA Canettieri
- Docente: ENRICO De Smaele
- Docente: maria pia felli
- Docente: Mariapia Felli
- Docente: ELISABETTA FERRETTI
- Docente: Giuseppe Giannini