The course aims to elucidate the primary theories concerning psychosexual development and the construction of gen-der identity, providing a historical perspective that highlights changes in psychodynamic understanding, diagnostic models, and psychological intervention and treatment. In the psychodynamic realm, the comprehension of gender identity and sexuality has a long and controversial history. The goal of this course is to reconstruct the main phases of this history to arrive at a contemporary and complex reading of the various topics. Special attention will be given to the most recent advancements in diagnosis and treatments, occurring in light of a new understanding of sexual orienta-tions and gender identities. The course intends to provide an exhaustive preparation on concepts of psychosexual de-velopment, infantile sexuality, gender identity, gender incongruence, with extensive sections dedicated to the presenta-tion of clinical cases. Traversing the developmental arc from early childhood to adulthood, the course aims to provide a deep understanding of core concepts of gender identity, gender constancy, gender typicality, gender intensification, gender role, gender incongruence, and gender dysphoria. The program includes an examination of these themes with-in a clinical, scientific, and cultural comprehension. Each topic will be explored in detail with particular reference to a multidisciplinary approach, based on a biopsychosocial model. In this "sexual century," as psychoanalyst Ethel Person termed it, psychoanalysis has learned much and has witnessed new contributions that allow us not only to under-stand better but also to treat more accurately various types of sexual expressions, behaviors, and feelings. Particular at-tention will be given to transgender and non-binary identities and to emerging forms of affective and sexual relation-ships (e.g., polyamory and asexuality). The course will involve lectures that provide ample space for discussion, shared reflection, conceptualization of clinical cases, and the designing of treatment plans. Various ethical issues related to psychological and psychotherapeutic interventions on matters concerning sexual orientation, gender identity, and sexual deviance will be considered. Special attention will be given to understudied areas of the clinical encounter with these populations, such as "countertransferential" issues of rejection and attraction in response to atypical sexual be-havior or non-conforming gender identities. The course thoroughly addresses topics such as sexual abuse, sexual trauma, and non-consensual sexual activity and anticipates active participation by students in discussing these topics. For this reason, the instructor will ensure that every discussion takes place in a safe and inclusive environment, guar-anteeing confidentiality regarding the issues addressed.