PROGRAM

-The concept of sorting signals

-Transport across the nuclear membrane: the nuclear pore complex as a gate for allowing bidirectional transport between nucleus and cytoplasm.

-Molecular characterization of the mechanisms involved in directing newly synthesized proteins to the secretory pathway. Crucial roles played by the endoplasmic reticulum in traslocation, glycosylation, folding.

-The ER quality control and ERAD: ER-retention of misfolded proteins, aggregation and polymers formation.

-Molecular signaling events activated after the retention of misfolded proteins in the ER: the unfolded protein response (UPR),

- Vesicular transport from the ER: to ERGIC and Golgi Apparatus. Vesicular coats.

The sorting station of the Trans Golgi Network: sorting to the lysosomes.

-Exocytosis and Endocytosis.

-Protein import in the mitochondria

-Molecular aspects of autophagy.

-Seminar classes on selected pathology: Cystic Fibrosis, Prions, Niemann Pick, Fenib, SLA, Alzheimer disease, Autism Spectrum Disorders