The program will be focused on analyzing the basic molecular and cellular mechanisms underlying the trafficking of mRNAs and proteins in the cell. The signals used for translocation through the membranes will be described together with the known quality control systems. For the sorting of the secretory proteins the role of the endoplasmic reticulum in monitoring folding and eventual protein degradation, will be deeply discussed. It will be approached the vesicular transport as a mean for moving proteins from different cellular compartments. Description of the known alterations to these basic cellular mechanisms will be described in association with specific diseases such as Alzheimer, Prions, Fenib and Autism Spetrum Disorders.