The subject of this class is the use of space technologies for astrophysics measurements. After and introduction detailing the importance of space-based measurements in astrophysics and the main applications, basic elements of space carriers, orbits, attitude control, space cryogenics, detectors, telemetry systems are analyzed, with specific reference to sample astrophysics missions. Also, the different phases of the development of a space mission are described from a management and development point of view. The class is complemented by visits to the Italian Space Agency and the Istituto Nazionale di Geofisica premises and facilities.