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  • Dottorato MIT - Presentazione (IT)

    Università di Roma "La Sapienza"

    Dipartimento SAIMLAL - Sezione di Istologia ed Embriologia Medica

    via Scarpa 16, 00161 Roma Tel. 06 49 76 68 03 Fax 06 44 62 854

    Dottorato di Ricerca in Morfogenesi e Ingegneria Tissutale

    Coordinatore: Prof. Antonio Musarò, -antonio.musaro@uniroma1.it

    Segreteria: dottoratomit.saimlal@uniroma1.it

    Questo dottorato, afferente alla Scuola di dottorato in Biologia e Medicina Molecolare - BeMM, si propone di fornire gli strumenti conoscitivi, critici e metodologici per lo svolgimento di attività di ricerca - di base, applicata, traslazionale - di elevato livello qualitativo nel settore biomedico, farmaceutico e biotecnologico. Per il conseguimento di questi obiettivi i corsi sono finalizzati all'acquisizione da parte dei dottorandi non solo di contenuti informativi, mutevoli per il rapido evolversi delle conoscenze, ma anche, soprattutto, di criteri valutativi per la individuazione di problemi specifici irrisolti alla luce delle conoscenze attuali e delle possibili strategie sperimentali per la loro soluzione. 

    Il dottorato è articolato in tre curricula: 

    Curriculum in Scienze Morfogenetiche e Citologiche Gli obiettivi formativi si articolano in linee di ricerca che consistono nello studio dei meccanismi che regolano il differenziamento di cellule somatiche in relazione a: a) l'espressione ed il mantenimento dello stato differenziato ed in particolare il ruolo regolativo di molecole informative attive nella miogenesi (AVP, TGFb e IGF I) e delle vie di trasduzione da esse attivate - in particolare di PKC. b) l'embriogenesi ed l'istogenesi, studiando in particolare i fenomeni di induzione e di determinazione delle strutture mesodermiche e la genesi ed il ruolo del compartimento staminale e dei precursori miogenici; c) l'identificazione dei meccanismi molecolari alla base del differenziamento mieloide della cellula staminale emopoietica in modelli di differenziamento mieloide e di leucemogenesi; d) l'ingegneria tessutale, in particolare costruzione di miotubi organizzati in una bio-struttura trapiantabile impiegati per la ri-colonizzazione funzionale del muscolo scheletrico e cardiaco, e studi di ricolonizzazione di scaffold muscolari de-cellularizzati; e) rimodellamento cardiaco, attraverso la caratterizzazione delle basi molecolari dello scompenso cardiaco, del ruolo di fattori infiammatori e di isoforme di PKC nell'instaurarsi dell'ipertrofia. 

    Curriculum in Scienze e Tecnologie Cellulari Le tematiche su cui è incentrato il percorso formativo di questo curriculum del Dottorato sono: a) la regolazione del ciclo cellulare e dell'apoptosi: studio di regolatori molecolari delle vie intrinseca ed estrinseca di induzione dell’apoptosi, rapporti con i meccanismi che regolano il ciclo, sistemi di protezione dalla morte cellulare; b) la biologia delle cellule staminali spermatogoniali, è volta all’isolamento e alla caratterizzazione delle cellule staminali della spermatogenesi nei mammiferi incluso l’uomo, prerequisiti per il loro potenziale utilizzo in terapia medica, per la cura e prevenzione dell’infertilità e nei tumori delle cellule germinali. c) la regolazione dell'espressione genica e del differenziamento, con interesse verso i meccanismi del differenziamento della linea germinale maschile e femminile durante lo sviluppo delle gonadi e i segnali molecolari paracrini della componente somatica. d) le interazioni cellulari e la morfogenesi, con riferimento allo sviluppo delle gonadi, l'istogenesi di specifiche popolazioni cellulari delle gonadi, i meccanismi morfogenetici nello sviluppo di tubuli seminiferi e follicoli ovarici; e) omeostasi tissutale e trasformazione neoplastica: meccanismi di interazione fra alterazioni dell’omeostasi tissutale indotte da stimoli infiammatori (citochine e/o agenti che mimano infezioni patogene) e carcinogenesi o progressione tumorale in linee cellulari di vari tipi di iperplasia e di carcinoma e in vivo in modelli murini di xenotrapianti o ortotopici; cross-talk tra le vie di segnalazione attivate dai recettori dell’immunità innata e dagli oncogeni nell’instaurarsi dei fenotipi trasformati; ruolo dei meccanismi immunosoppressivi attivati nelle cellule tumorali e strategie per ripristinare la sorveglianza immunitaria antitumorale. 

    Curriculum in Biofisica Cellulare e Tissutale Il Curriculum in Biofisica Cellulare e Tissutale ha l’obiettivo di avviare i propri studenti ad inserirsi nelle attività di ricerca scientifica e professionali, sviluppando le loro capacità di gestione autonoma, efficiente e critica di un progetto di ricerca originale grazie all'acquisizione di competenze in: - fondamenti di biologia, fisiologia, biochimica e biologia molecolare dell'uomo; - tecniche di acquisizione ed analisi di biosegnali e immagini di interesse biomedico; - tecniche di modellizzazione dinamica di biosistemi. 

     

    Modalità concorsuali: https://www.uniroma1.it/it/pagina/dottorati-di-ricerca

    vedere anche sezione specifica

    Scuola di dottorato in Biologia e Medicina Molecolare - BeMM

    Ph.D. School in Molecular Biology & Medicine - BeMM

  • MIT Phd Course Presentation

    "Sapienza" University of Rome

    SAIMLAL Department - Histology and Medical Embryology Section - via Scarpa 16, 00161 Roma Tel. 06 49 76 68 03

    PhD Program in Morphogenesis & Tissue Engineering

    Coordinator: Prof. Antonio Musarò- email: antonio.musaro@uniroma1.it

    Reference person: Gabriella Fedele -- 06 4443 8104  (x28104) - gabriella.fedele@uniroma1.it

    This PhD program is part of the School of Doctorate in Biology and Molecular MedicineThe overall aim of the PhD program is to provide cultural, analytical and methodological tools to perform high level-, basic- or traslational- or applied-, research in the biomedical, pharmaceutical and biotechnological fields. 

    For this purpose, the courses are aimed to teach the students not only notions (rapidly changing and evolving) but also: a) to acquire evaluation criteria to innovatively pinpoint unresolved issues, in specific fields; b) to design experimental strategies which address these issues. 

    Curriculum in Morphogenetic and Cytological Sciences The didactic aims of the PhD program are developed through research guidelines regarding the study of the mechanisms regulating somatic cell differentiation. In particular, the following research interests are pursued: 

    • Progression and maintenance of the differentiated state, through interaction between muscle cells and factors regulating myogenesis such as AVP, TGFbeta and IGF-I. Role of signal transduction pathways activated by IGF-I and TPA, through PKC isoforms. 
    • Embryogenesis and histogenesis. In particular, the mechanisms of induction and determination of mesodermal structures ,as well as of the genesis and role of stem and myogenic precursor cells. 
    • Identification of molecular mechanisms of myeloid differentiation of hematopoietic stem cells, exploiting models of normal myeloid differentiation and of leukemogenesis; 
    • Tissue engineering, with special interest for the construction of engineered myotubes organized into an implantable biostructure, and studies of re-colonization of decellularized scaffolds by myogenic cells; 
    • Molecular mechanisms of cardiac remodeling, homeostasis an hypertrophy. 

    Curriculum in Cell Sciences and Technologies The main areas of training for this curriculum are: 

    • Mechanisms controlling cell cycle and death, a primary interest being devoted to the study of molecular regulators of the intrinsic and extrinsic apoptosis pathways.
    • Cell interactions and morphogenesis, with reference to the development of the gonads, the histogenesis of gonadic cell population and the morphogenesis of seminiferous tubules and ovarian follicles 
    • Biology of spermatogonial stem cell, with emphasis on the isolation and characterization of mammalian germline stem cells, prerequisite for their potential use in medical therapy of infertility and of testis germ cell tumors. 
    • Regulation of gene expression and cell differentiation, with reference to the mechanisms of male and female germline differentiation during gonads formation and paracrine signaling by somatic cells. 
    • Tissue homeostasis and malignant transformation: interplay between tissue homeostasis changes induced by inflammatory agents (cytokines and/or agents mimicking pathogen infections) and carcinogenesis or tumour progression in hyperplasic and carcinoma cells and in "in vivo" mouse models of orthotopic- and xeno-transplants; cross talk between signal pathways activated by receptors of innate immunity and oncogenes in the onset of transformed phenotype; immunosuppressive mechanisms developed by tumour cells and strategies to restore anti-tumour immunosurveillance. 

    Curriculum in Cell and Tissue Biophysics The educational focus of the Curriculum in BIOPHYSICS is the endorsement of scientific and professional skills in dealing with basic biophysical problems, paying special attention to the autonomous and appropriate appreciation of relevant issues. In particular, the realization of original research projects is encouraged and sustained in the following fields:

    • mathematical modeling, multivariate statistics and biophysical chemistry;
    • spectroscopical methods;
    • human biology, molecular genetics and brain metabolism;
    • dynamical simulations and modeling of biosystems at different dimensional scale.

     Additional info at: https://phd.uniroma1.it/web/MORFOGENESI-E-INGEGNERIA-TISSUTALE_nD3525_IT.aspx

    Admission Procedures

    The announcement for the admission is published each year at https://www.uniroma1.it/it/pagina/dottorati-di-ricerca

    "La Sapienza” University announces each year an open, exam-based competition, for the admission to the current cycle of the Ph.D program. The call is usually published in June-July. It lists the "La Sapienza” University courses: perspective PhD students are encouraged to apply to Code: 26083 Morphogenesis and Tissue Engineering

    The date, the time and location of the oral exam (prova orale) are indicated together with contact person (referente) name, telephone number and email address.

    Applications from candidates, regardless of gender, age and nationality, who hold an Italian “diploma di laurea/laurea specialistica/laurea magistrale”, or an equivalent second-level degree (generally equivalent to a Master’s Degree) obtained abroad (or expecting to receive their degree by October 31 of each year) are welcome. The equivalence of each qualification to the relevant Italian degree will be ascertained, for the sole admission to these competitions, by the Academic Board of the course, within the area of interuniversity agreements of cooperation and mobility.

    School of Doctorate in Biology and Molecular Medicine Logo BeMM

  • Concorso 38° ciclo MIT / MIT Admission 37 cycle

    COD. 26083 MORFOGENESI E INGEGNERIA TISSUTALE

    Sede: Dipartimento di Scienze anatomiche, istologiche, medico-legali e dell'apparato locomotore

    Coordinatore: Prof. Antonio Musarò


    - Tipologia B: 1 borsa Sapienza (importo maggiorato CN)
    - Tipologia C: 1 borsa DM 351/2022 su specifica tematica – Ricerca PNRR CUP - B83C22003610006
    - Tipologia F: 1 borsa esterna finanziata da ISS su specifica tematica
    - Tipologia G: 7 borse Sapienza - 3 posti senza borsa

     

    La scadenza per la presentazione delle domande è fissata inderogabilmente al 25 agosto 2022.

    Deadline for documents presentation on August 25, 2022

     

    Curricula:

    a. SCIENZE MORFOGENETICHE E CITOLOGICHE

    b. SCIENZE E TECNOLOGIE CELLULARI

    c. BIOFISICA CELLULARE E TISSUTALE

     

    Candidates wishing to apply for a PhD position can find information on the procedures, methods, and deadlines by connecting to the Sapienza website (https://www.uniroma1.it/it/pagina/dottorati-di-ricerca) Call for applications of XXXVIII cycle.

    The qualifications are estimated according to the evaluation criteria defined by the Doctoral Teaching Council (the evaluation grid is available in the call for applications).


  • Research Projects related to 38 cycle

  • Collegio dei Docenti - Scholars

  • Dottorandi - Ph.D. Students

    XXXV

    BARBONARI SAMANTHA

    CASTALDO VITTORIO

    ESPOSITO GABRIELLA

    FORCONI FLAVIA

    IAIZA ALESSIA

    INFANTE JESSICA

    LICCARDO FRANCESCA

    MASI ILENIA

    MILLOZZI FRANCESCO 

    MONTI NOEMI

    NANDIMANDALAM MANASA

    RONCA VINCENZO

    TARTARELLI IRENE

    VOZZI ALESSIA

    SABINO BRUNA

    XXXIV

    ALEXANDRA, AURIANE, PATRICIA BENONI
    MARCO BETTIOL
    CHIARA CAPPONI
    IRENE CASOLA
    GIORGIA CATARINELLA
    ELENA CRECCA
    RICCARDO DE FEO
    ANA GABRIELA DE OLIVEIRA DO REGO
    MARTINA GENTILE
    LUISA GESUALDI
    JACOPO MORRONI
    PIERONI NICOLA
    MARIANO PONTICO
    SILVIA SIDERI

    XXXIII

    ANTONIO CAPALBO
    MARCO CECCANTI
    MARIANNA COSENTINO
    RICCARDO DI SANTO
    ILENIA GIORDANI
    FEDERICO GIULITTI
    MARIACONCETTA LONGO
    MIRKO MININI
    GIADA PONTECORVI
    DAISY PROIETTI
    ALESSANDRA RENZINI
    THAYS MARIA SILVA CARVALHO
    MARILENA TAGGI

    XXXII

    ANNA BENEDETTI
    EUGENIU CRISTIAN BORU
    ANGELO CIRCELLI
    ANTONELLA D'AMORE
    MARIA GIOVANNA DI TRANI
    ROSARIA ANNA FONTANELLA
    ADRIANO GIANCANI
    MEDHI HASSANI
    ERICA LEONETTI
    CARMEN MIANO
    MANDATORI SARA
    NICOLINA SCIARAFFA
    JOSE JAIRO TEIXEIRA DA SILVA
    CLAUDIA TITO
    LUCA TUCCIARONE

    XXXI

    FRANCESCA ASCENZI
    MARIA RITA ASSENZA
    ERNESTINA CAPUANO
    CLOTILDE CASTALDO
    DANIELE COSTANTINI
    BATTAFARANO GIULIA
    MICHELE GUERRERI
    ENRICA MODICA
    VALENTINA MULARONI
    ALBERTO QUATTROCCHI
    DARIO ROSSI
    ROSSANA SARACINO
    LUANA TOMAIPITINCA
    GARIMA VERMA

    XXX

    ARIANNA BRANCACCIO
    MARISA CAPPELLA
    DANILO CIMADOMO
    KATIA CORANO SCHERI
    RITA DE SANCTIS
    GIANLUCA DI FLUMERI
    MARTA DI MARTILE
    LAURA FORCINA
    FEDERICA INNOCENTI
    SILVIA PALMERIO
    FRANCESCA PAPACCI
    EVA PIGNA
    CLAUDIA POLITO
    MARTINA SANDONÀ
    FRANCESCA SCATOZZA

    XXIX

    ALEXANDRA BACCAM
    TERESA BELLISSIMO
    RITA DE GAETANO
    ANNA LAURA DI PACE
    SARA DI PERSIO
    CHIARA DI STEFANO
    VALENTINA ESPOSITO
    PIERA FILOMENA FIORE
    FEDERICO FIORELLI
    BIAGINA GIUSEPPA MAIMONE
    SIMONA PISU
    ENRICA URCIUOLI

    XXVIII

    SILVIA CONTI
    MICAELA CONTU
    MARTINA CORDELLA
    ELIA MARGARITA CORNELIO MARI
    MARCO CORSI
    MASSIMO COSENZA
    ETTORE COSTA
    ROSSANA COTRONEO
    LUCA CRETARA
    LUCA CRISTOFANO
    GIUSEPPE CUCINOTTA
    ROBERT NEIL CUNLIFFE
    VIRGINIA DI PAOLO
    MARTINA FARALDI
    ADRIANA FARENGA
    MAHMOUD FAROUK MAHMOUD MOHAMADAIN
    VALERIA MARROCCO
    NICOLETTA MARRONCELLI
    MARTINA MARTINI
    CARMELA MARTIRE
    IRENE PAFUMI
    CATELLO SCARICA

  • Pubblicazioni Dottorandi MIT 2015-2017

    Pubblicazioni 2015-2017

    Pubblicazioni dei Dottorandi in Morfogenesi e Ingegneria Tissutale


    1.      A. Del Fattore, R. Luciano, R. Saracino, G. Battafarano, C. Rizzo, L. Pascucci, G. Alessandri, A. Pessina, A. Perrotta, A. Fierabracci, M. Muraca.   Differential effects of extracellular vesicles secreted by mesenchymal stem cells from different sources on glioblastoma cells.                   Expert Opin Biol Ther. 2015 Apr;15(4):495-504.

    2.      Assenza M.R, et al. (2017) Critical role of Phosphodiesterase 2A in congenital heart defects. Abstract, Cardiovascular Development Meeting

    3.      Assenza M.R, et al. (2017) Critical role of Phosphodiesterase 2A in mouse congenital heart defects. Card. Res. submitted

    4.      Baccam A, Hassani M, Sviercovish-Benoni A, Adamo S, Moresi V, Coletti D. Basking in their Niche: Stem Cells with Myogenic Potential as a Target to Combat Cachexia. Curr Updates in Stem Cell Res and Ther. 2017, 1: 1.1

    5.      Baccam A, Ramella M, Boccafoschi F, Mericskay M, Li Z, Coletti D.    Molecular pathways involved in the crosstalk between cytokines and mechanical cues in cancer cachexia.   J Cachexia Sarcopenia Muscle. 2016 Sep; 7(4): 501–502. doi:  10.1002/jcsm.12141

    6.      Bellissimo T., Ganci F., Gallo E., Sacconi A., Tito C., De Angelis L.,  Pulito C., Masciarelli S., Diso D., Anile M.,  Petrozza V., Giangaspero F., Pescarmona E., Facciolo F., Venuta F., Marino M., Blandino G., and Fazi F. Thymic Epithelial Tumors phenotype relieson miR-145-5p epigenetic regulation. Mol Cancer. 2017 May 10;16(1):88.

    7.      Bellissimo T., Russo E., Ganci F., Vico C., Vitolo D., Anile M., Disio D., Marino M., Blandino G., Venuta F., Fazi F.                   Circulating miR-21-5p and miR-148a-3p as emerging non-invasive biomarkers in thymic epithelial tumors.   Cancer Biology & Therapy; 2016, 17(1):79-82

    8.      Bellissimo T.; Ganci F.; Galllo E., Sacconi A.; Tito C.; De Angelis L.; Diso D.; Anile A.; Petrozza V.; Giangaspero F.; Pescarmona E.; Facciolo F; Venuta F; Marino M.; Blandino G.; Fazi F.         Thymic Epithelial Tumors phenotype relies on miR-145-5p epigenetic regulation.            Molecular Cancer; 2016

    9.      Bettiol M., Preziosi E., Cinti M. N., Borrazzo C., Fabbri A., Cassano B., Polito C., Pellegrini R. and Pani R., A Depth-of-Interaction encoding method for SPECT monolithic scintillation detectors. JOURNAL OF INSTRUMENTATION 2016, vol. 11(12); p. C12054-C12054, ISSN: 1748-0221, doi: 10.1088/1748-0221/11/12/C12054.

    10.    Boffito M, Di Meglio F, Mozetic P, Giannitelli SM, Carmagnola I, Castaldo C, Nurzynska D, Sacco AM, Miraglia R, Montagnani S, Vitale N, Brancaccio M, Tarone G, Basoli F, Rainer A, Trombetta M, Ciardelli G, Chiono V. Polyurethane scaffolds surface functionalised with bioactive proteins: physicochemical properties and influence on the in vitro behaviour of human cardiac primitive cells. Biomaterials Science, under review.

    11.    Boitani C, Di Persio S, Esposito V, Vicini E. Spermatogonial cells: mouse, monkey and man comparison. Semin Cell Dev Biol. 2016 Mar 5. pii: S1084-9521(16)30068-4. doi: 10.1016/j.semcdb.2016.03.002.

    12.    Brancaccio A, Palacios D.                  Chromatin signaling in muscle stem cells: interpreting the regenerative microenvironment.         Front Aging Neurosci. 2015 Apr 7;7:36. doi: 10.3389/fnagi.2015.00036.

    13.    C Boru, Pierro Giustacchini, Francesco Greco, Marco Raffaelli, Gianfranco Silecchia. Indications and outcomes of sleeve gastrectomy conversion to gastric bypass surgery: multicenter retrospective study. Sottoposta a pubblicazione agosto 2017 al Journal of Obesity Surgery

    14.    Cananzi FC, Mussi C, Bordoni MG, Marrari A, De Sanctis R, Colombo P, Quagliuolo V. Role of surgery in the multimodal treatment of primary and recurrent leiomyosarcoma of the inferior vena cava. J Surg Oncol. 2016 Jul;114(1):44-9.

    15.    Capalbo A, Cimadomo D, Ubaldi FM, Rienzi L.  Comprehensive chromosomal screening from polar body biopsy to blastocyst trophectoderm sampling: evidences and considerations, chapter 7 in Screening the Single Euploid Embryo: Molecular Genetics in Reproductive Medicine by E Scott. Springer ed. 1, 2015.

    16.    Capalbo A, Romanelli V, Cimadomo D, Girardi L, Stoppa M, Dovere L, Dell'Edera D, Ubaldi FM, Rienzi L. Implementing PGD/PGD-A in IVF clinics: considerations for the best laboratory approach and management.    J Assist Reprod Genet. 2016 Oct;33(10):1279-1286.

    17.    Capalbo A, Treff NR, Cimadomo D, Tao X, Upham K, Ubaldi FM, Rienzi L, Scott RT Jr.  Comparison of array comparative genomic hybridization and quantitative real-time PCR-based aneuploidy screening of blastocyst biopsies.         Eur J Hum Genet. 2015 Jul;23(7):901-6. doi: 10.1038/ejhg.2014.222.

    18.    Capalbo A, Ubaldi FM, Cimadomo D, Maggiulli R, Patassini C, Dusi L, Sanges F, Buffo L, Venturella R, Rienzi L.    Consistent and reproducible outcomes of blastocyst biopsy and aneuploidy screening across different biopsy practitioners: a multicentre study involving 2586 embryo biopsies. Hum Reprod. 2016 Jan;31(1):199-208. doi: 10.1093/humrep/dev294.

    19.    Caporale A, Palombo M, Macaluso E, Guerreri M, Bozzali M, Capuani S.            The γ-parameter of Anomalous Diffusion quantified in human brain by MRI depends on local magnetic susceptibility differences.        NeuroImage. 2016 147: 619-631

    20.    Caporale A., Palombo M., Macaluso E., Guerreri M., Bozzali M., & Capuani S. (2017). The γ-parameter of anomalous diffusion quantified in human brain by MRI depends on local magnetic susceptibility differences. Neuroimage, 147, 619-631.

    21.    Capuani S., Guerreri M., Antonelli A., Bernardo S., Porpora M. G., Giancotti A., ... & Manganaro L. (2017). Diffusion and perfusion quantified by Magnetic Resonance Imaging are markers of human placenta development in normal pregnancy. Placenta, 58, 33-39.

    22.    Capuano E., Masciarelli S., Ottone T., Divona M., De Panfilis S., Noguera N.I., Lo-Coco F. and F. Fazi “Development of a combination strategy based on ER and oxidative stress in Acute Myeloid Leukemia”. 7th International Symposium on Acute Promyelocitic Leukemia. Rome, 24-27 September 2017

    23.    Capuano E., Masciarelli S., Ottone T., Divona M., De Panfilis S., Noguera N.I., Lo-Coco F. and F. Fazi “Development of a combination strategy based on ER and oxidative stress in Acute Myeloid Leukemia”. ABCD Congress. Bologna, 21-23 Settembre 2017

    24.    Cardinali B, Cappella M, Provenzano C, Garcia-Manteiga J, Lazarevic D, Cittaro D, Martelli F, Falcone G.   MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells.          Cell Death and Disease 2016; 7, e2086; doi:10.1038/cddis.2016.10

    25.    Cartocci G,  Maglione  A G, Rossi  D, Modica E, Malerba P , Babiloni F.                The influence of different cochlear implant features use on the mental workload index during a word in noise recognition task. International Journal of Bioelectromagnetism Vol. 18, No. 2, pp. 60 - 66, 2016

    26.    Cartocci G,  Maglione  A G, Rossi  D, Modica E, Malerba P , Babiloni F.                  The influence of different cochlear implant features use on the mental workload index during a word in noise recognition task. International Journal of Bioelectromagnetism Vol. 18, No. 2, pp. 60 - 66, 2016

    27.    Cartocci G, Caratù M, Modica E, Maglione AG, Rossi D, Cherubino P, Babiloni F. Electroencephalographic, Heart Rate, and Galvanic Skin Response Assessment for an Advertising Perception Study: Application to Antismoking Public Service Announcements. JoVe. 2017 Aug 28; (126). Doi: 10.3791/55872

    28.    Cartocci G, Cherubino P, Rossi D, Modica E, Maglione A G, Di Flumeri G, Babiloni F .           Gender and Age Related Effects While Watching TV Advertisements: An EEG Study. Epub 2016 May 26. Comput Intell. 2016;2016:3795325. doi: 10.1155/2016/3795325.

    29.    Cartocci G, Cherubino P, Rossi D, Modica E, Maglione A G, Di Flumeri G, Babiloni F .          Gender and Age Related Effects While Watching TV Advertisements: An EEG Study. Epub 2016 May 26.          Comput Intell. 2016;2016:3795325. doi: 10.1155/2016/3795325.

    30.    Cartocci G, Modica E, Rossi D, Maglione AG, Venuti I, Rossi G, Corsi E, Babiloni F. A pilot study on the neurometric evaluation of "effective" and "ineffective" antismoking public service announcements. Annual international conference of the IEEEE Engineering in Medicine and Biology Society. 2016 August; 2016:4597-4600. Doi: 1109/EMBC.2016.7591751

    31.    Cartocci, Giulia; Caratù, Myriam; Modica, Enrica; Maglione, Anton Giulio; Rossi, Dario; Cherubino, Patrizia; Babiloni, Fabio; "Electroencephalographic, Heart Rate, and Galvanic Skin Response Assessment for an Advertising Perception Study: Application to Antismoking Public Service Announcements.",Journal of visualized experiments: JoVE,126,2017,

    32.    Caruso M, Ferranti F, Corano Scheri K, Dobrowolny G,  Ciccarone F, Grammatico P, Catizone A, Ricci G. RSpondin-1/Dickkopf-1/beta-catenin machinery is involved in testicular embryonic angiogenesis. PLoS One 2015 Apr 24;10(4):e0124213. doi: 10.1371/journal.pone.0124213.

    33.    Catizone A, Ricci G, Caruso M, Galdieri M, Corano Scheri K, Di Paolo V and Canipari R.     HGF Modulates Actin Cytoskeleton Remodeling and Contraction in Testicular Myoid Cells. Biomedicines 2015, 3(1), 89-109; doi:10.3390/biomedicines3010089

    34.    Catizone A.; Ricci G.; Caruso M.; Galdieri M.; Corano Scheri K.; Di Paolo V and Canipari R. “HGF Modulates Actin Cytoskeleton Remodeling and Contraction in Testicular Myoid Cells” Biomedicines 2015, 3(1), 89-109

    35.    Cherubino P, Cartocci G, Trettel A, Rossi D, Modica E, Maglione A G, Mancini M, Di Flumeri G, Babiloni F. Marketing Meets Neuroscience: Useful Insights for Gender Subgroups During the Observation of TV Ads. Applying Neuroscience to Business Practice, IGI Global, chapter 8, p. 163-190 (2016).

    36.    Cherubino P, Cartocci G, Trettel A, Rossi D, Modica E, Maglione A G, Mancini M, Di Flumeri G, Babiloni F. Marketing Meets Neuroscience: Useful Insights for Gender Subgroups During the Observation of TV Ads. Applying Neuroscience to Business Practice, IGI Global, chapter 8, p. 163-190 (2016).

    37.    Cherubino P., Trettel A., Cartocci G., Rossi D., Modica E., Maglione A.G., Mancini M., Di Flumeri G., Babiloni F.   Neuroelectrical Indexes for the Study of the Efficacy of TV Advertising Stimuli. In Select Issues of Experimental Economics (pp. 355-371). Springer International Publishing, 2016

    38.    Cherubino P., Trettel A., Cartocci G., Rossi D., Modica E., Maglione A.G., Mancini M., Di Flumeri G., Babiloni F. Neuroelectrical Indexes for the Study of the Efficacy of TV Advertising Stimuli. In Select Issues of Experimental Economics (pp. 355-371). Springer International Publishing, 2016

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    121.  Preziosi E., Pani R., Trigila C., Polito C., Bettiol M., Borrazzo C., Cinti M. N., Fabbri A., Pellegrini R. and Pani R., A crystal identification method for monolithic phoswich detectors based on scintillation light distribution. JOURNAL OF INSTRUMENTATION 2016, vol. 11(12); p. P12009-P12009, ISSN: 1748-0221, doi: 10.1088/1748- 0221/11/12/P12009.

    122.  Puzzo D, Raiteri R, Castaldo C, Capasso R, Pagano E, Tedesco M, Gulisano W, Drozd L, Lippiello P, Palmeri A, Scotto P, Miniaci MC. CL316,243, a β3-adrenergic receptor agonist, induces muscle hypertrophy and increased strength. Sci Rep. 2016 Nov 22; 5:37504. doi: 10.1038/srep37504.

    123.  R. Luciano, R. Saracino, G. Battafarano, A. Perrotta, M. Manco, M. Muraca, A. Del Fattore.                 New perspectives in glioblastoma: Nanoparticles-based approaches.             Current Cancer Drug Targets, ePub 2016 Aug 13- PMID: 27528362

    124.  R. Luciano, R. Saracino, G. Battafarano, A. Perrotta, M. Manco, M. Muraca, A. Del Fattore. New perspectives in glioblastoma: Nanoparticles-based approaches. Current Cancer Drug Targets, 2017;17(3):203-220

    125.  R. Saracino, R. Luciano, G. Battafarano, A. Perrotta, M. Muraca, A. Del Fattore.                  Nanoparticles-based treatment for bone metastasis.                     Current Drug Targets. 2016;17(3):303-10

    126.  R. Saracino, R. Luciano, G. Battafarano, A. Perrotta, M. Muraca, A. Del Fattore. Nanoparticles-based treatment for bone metastasis. Current Drug Targets. 2016;17(3):303-10

    127.  Rienzi L, Bariani F, Dalla Zorza M, Romano S, Scarica C, Maggiulli R, Nanni Costa A, Ubaldi FM. Failure mode and effects analysis of witnessing protocols for ensuring traceability during IVF. Reprod Biomed Online. 2015 Oct;31(4):516-22. doi: 10.1016/j.rbmo.2015.06.018.

    128.  Rienzi L, Capalbo A, Stoppa M, Romano S, Maggiulli R, Albricci L, Scarica C, Farcomeni A, Vajta G, Ubaldi FM. No evidence of association between blastocyst aneuploidy and morphokinetic assessment in a selected population of poor-prognosis patients: a longitudinal cohort study. Reprod Biomed Online. 2015 Jan;30(1):57-66. doi: 10.1016/j.rbmo.2014.09.012.

    129.  Rizzuto E, Carosio S, Faraldi M, Pisu S, Musarò A, Del Prete Z. A DIC Based Technique to Measure the Contraction of a Skeletal Muscle Engineered Tissue. Applied Bionics and Biomechanics, Epub 2016 Mar 9; 2016:7465095. doi: 10.1155/2016/7465095.

    130.  Rizzuto E, Pisu S, Musarò A, Del Prete Z. Measuring Neuromuscular Junction Functionality in the SOD1G93A Animal Model of Amyotrophic Lateral Sclerosis. Annals of Biomedical Engineering, 2015 Sep;43(9):2196-206. doi: 10.1007/s10439-015-1259-x.

    131.  Sandonà M, Consalvi S, Tucciarone L, Puri PL, Saccone V. HDAC inhibitors for muscular dystrophies: progress and prospects.
Expert Opinion on Orphan Drugs, 2015 Dec 29, 4:2, 125-127, DOI: 10.1517/21678707.2016.1130617

    132.  Sandonà M. Consalvi S. Tucciarone L. Puri P.L. and Saccone V HDAC inhibitors for muscular dystrophies: progress and prospects”.

    133.  Saracino R, Luciano R, Battafarano G, Perrotta A, Muraca M, Del Fattore A (2015). Nanoparticles-Based Treatment for Bone Metastasis. Current drug targets, vol. 17; p. 303-310, ISSN: 1389-4501, doi: 10.2174/1389450116666150427154706#sthash.QLNyWVK1.dpuf

    134.  Signaroldi E, Laise P, Cristofanon S, Brancaccio A, Reisoli E, Atashpaz S, Terreni MR, Doglioni C, Pruneri G, Malatesta P, Testa G.  Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network.      Nat Commun. 2016 Feb 29;7:10753. doi: 10.1038/ncomms10753.

    135.  Silvia Galardi, Mauro Savino, Fiorella Scagnoli, Serena Pellegatta, Federica Pisati, Federico Zambelli, Barbara Illi, Daniela Annibali, Sara Beji, Elisa Orecchini, Maria Adele Alberelli, Clara Apicella, Rosaria Anna Fontanella, Alessandro Michienzi, Gaetano Finocchiaro, Maria Giulia Farace, Giulio Pavesi, Silvia Anna Ciafrè, Sergio Nasi. Resetting cancer stem cell regulatory nodes upon MYC inhibition , 2016, EMBO reports 17, 1872-1889.

    136.  Sirico F, Ricca F, DI Meglio F, Nurzynska D, Castaldo C, Spera R, Montagnani S. Local corticosteroid versus autologous blood injections in lateral epicondylitis: meta-analysis of randomized controlled trials. Eur J Phys Rehabil Med. 2016 Sep 1. [Epub ahead of print].

    137.  Sirico F, Ricca F, DI Meglio F, Nurzynska D, Castaldo C, Spera R, Montagnani S. Local corticosteroid versus autologous blood injections in lateral epicondylitis: meta-analysis of randomized controlled trials. Eur J Phys Rehabil Med, 53(3):483-491, 2017.

    138.  Sorci, M., Larivera, S., Cruciani, S.,  Capuano, E., Bozzoni, I., Fazi, F., Fatica A. “Unraveling the function of m6A modification in acute myeloid leukemia”. XIV FISV Congress. Rome, 20-23 September 2016.

    139.  Tabolacci C, Cordella M, Turcano L, Rossi S, Lentini A, Mariotti S, Nisini R, Sette G, Eramo A, Piredda L, De Maria R, Facchiano F, Beninati S.      Aloe-emodin  exerts a potent anticancer and immunomodulatory activity on BRAF-mutated human melanoma cells.               Eur J Pharmacol. 2015 Sep 5;762:283-92. doi: 10.1016/j.ejphar. 2015.05.057. Epub 2015 Jun 3.

    140.  Trisciuoglio D, Desideri M, Farini V, De Luca T, Di Martile M, Tupone MG, Urbani A, D'Aguanno S, Del Bufalo D.  Affinity purification-mass spectrometry analysis of bcl-2 interactome identified SLIRP as a novel interacting protein. Cell Death Dis. 2016 Feb 11;7:e2090. doi: 10.1038/cddis.2015.357.

    141.  Tucciarone, L,  Etxaniz, U,  Sandoná, M,  Consalvi, S,  Puri, P,  Saccone, V., Advanced methods to study the cross talk between fibro-adipogenic progenitors and muscle stem cells, Methods in Molecular Biology, 1687, 2018, 231-256

    142.  Ubaldi FM, Capalbo A, Colamaria S, Ferrero S, Maggiulli R, Vajta G, Sapienza  F, Cimadomo D, Giuliani M, Gravotta E, Vaiarelli A, Rienzi L.         Reduction of multiple pregnancies in the advanced maternal age population after implementation of an elective single embryo transfer policy coupled with enhanced embryo selection: pre- and post-intervention study.                  Hum Reprod. 2015 Sep;30(9):2097-106. doi: 10.1093/humrep/dev159.

    143.  Ubaldi FM, Capalbo A, Vaiarelli A, Cimadomo D, Colamaria S, Alviggi C, Trabucco E, Venturella R, Vajta G, Rienzi L.          Follicular versus luteal phase ovarian stimulation during the same menstrual cycle (DuoStim) in a reduced ovarian reserve population results in a similar euploid blastocyst formation rate: new insight in ovarian reserve exploitation.               Fertil Steril. 2016 Jun;105(6):1488-1495.e1. doi: 10.1016/j.fertnstert.2016.03.002.

    144.  V. Marrocco1, P. Fiore, A. Benedetti, S. Pisu, E. Rizzuto2, A. Musarò, L. Madaro3, B. Lozanoska-Ochser, M. Bouché Pharmacological Inhibition of PKCθ Counteracts Muscle Disease in a Mouse Model of Duchenne Muscular Dystrophy 12-JAN-2017 10.1016/j.ebiom.2017.01.001

    145.  Vaiarelli A, Cimadomo D, Capalbo A, Orlando G, Sapienza F, Colamaria S, Palagiano A, Bulletti C, Rienzi L, Ubaldi FM. Pre-implantation genetic testing in ART: who will benefit and what is the evidence?          J Assist Reprod Genet. 2016 Oct;33(10):1273-1278..

    146.  Venneri A.M, Giannetta E., Panio G., De Gaetano R., Gianfrilli D., Pofi R., Masciarelli S., Fazi F., Pellegrini M., Lenzi A., Naro F., Isidori A.               Chronic inhibition of PDE5 limits pro-inflammatory monocyte-macrophage polarization in streptozotocin-induced diabetic mice,  PLOS ONE; 11;10(5):e0126580.

    147.  Voellenkle, C., J.M. Garcia-Manteiga, S. Pedrotti, A. Perfetti, I. De Toma, D. Da Silva, B. Maimone, et al. 2016. “Implication of Long Noncoding RNAs in the Endothelial Cell Response to Hypoxia Revealed by RNA-Sequencing.” Scientific Reports 6. doi:10.1038/srep24141.

    148.  Zaccagnini, G., A. Palmisano, T. Canu, B. Maimone, F.M.L. Russo, F. Ambrogi, C. Gaetano, et al. 2015. “Magnetic Resonance Imaging Allows the Evaluation of Tissue Damage and Regeneration in a Mouse Model of Critical Limb Ischemia.” PLoS ONE 10 (11). doi:10.1371/journal.pone.014211.


  • MIT - Attività didattica 2018

    Corsi BeMM 2018


    Corso

    Anno

    Dottor

    Periodo

    CFU etc

    Inglese Scientifico

    I

    MIT

    GIU-LUG 2018

    3 CFU

    16 lezioni x 2 gruppi

    Banche dati  bibliografiche – cataloghi biblioteche – Open access

    I

    MIT

    27 (?) FEB 2018

    1 CFU

    Modulo 4 ore

    Sperimentazione Animale

    I

    IIHD/SIER

    in programmazione

    1 CFU

    Modulo 3 ore, x 3 gruppi

    Sicurezza in lab

    I

    IIHD/SIER MIT-MIMSP

    in programmazione

     

     

     

     

     

     

    Bioinformatics: Theory and Applications from Genomes to Drugs

    II

    B

    4 GIU - 4LUG

    3 CFU    26 ore

    Genomica e Medicina

    II

    BUGM

    in programmazione

    1 CFU - Modulo 4 ore

    Biostatistica

    II

    BCS

    in programmazione

    2 CFU    16 ore

    Fundamentals of Enzyme Kinetics

    (I) II

    B

    in programmazione

    12 ore, 1 CFU

    Drug Discovery & Delivery

    II

    SF

    ?

    2 CFU

     

     

     

     

     

    Biotecnologie e brevetti

    III

    SIER MIT

    ?

    1 CFU

    Scientific Writing – Comunicazione Scientifica – Public speaking?

    III

    IIHD/SIER - GBM

    ?

     

    9th BEMM  symposium

    III

    MIT

    autunno 2018

    1 CFU

    Sphingolipid signalling in mitochondrial apoptosis

    III, II, I

    B

    9-13 luglio

    1 CFU

    Spin off – Start up

    III

     

     

     

     

     

     

     

     




    b) Cicli di seminari di ricerca: 2 CFU (selezione dai cicli di seminari di ricerca 2017):

    • Study of the role of PKCTHETA in satellite cells behaviors in normal and dystrophic muscle
    • Valutazione delle modificazioni istopatologiche dopo l'applicazione di una nuova rete biosintetica assorbibile come rinforzo della iatoplastica per la
      iatoroscopia. Uno studio pilota per la riparazione del difetto
    • Ruolo della variante di spicing CD44V8-V10 nelle linee di carcinoma prostatico androgeno indipendenti PC3 e DU-145
    • Mechanism underlying exercise effects against cachexia: role of SRF as mechano-transductor
    • Cross-talk between cytokines and mechanical cues in cancer cachexia: an in vitro study
    • Mechanism of activation and role of TPC1 and TPC2 in health and desease
    • Studio del tessuto ghiandolare con tecniche di NMR in diffusione molecolare
    • Neurophysiological measurement for the online evaluation of mental states in operational environment
    • C-met activated pathways and their implication in TG CTS oncogenesis
    • HDACs activity on FAPs epigenic landscape during the progression of DMD
    • Role of phosphodiesterase5 in cardiovascular pathophisiology in spontaneously hypertensive rats and diabetc mice
    • TPC2 and Rabs interaction: Cross talk in cancer progression
    • Caratterizzazione cromosomica e funzionale di cellule escluse durante le prime fasi dell'embriogenesi umana
    • Ruolo dell'autofagia nel differenziamento delle cellule T-REG nell'ateroslerosi.
      Impatto dei lncRNA nei tumori epiteliali timici
    • Role of IL-6 signaling in muscle homeostasis and pathology
    • Retinite pigmentosa
    • Signal dependent regulation of polycomb repressive complex2 in muscle derived tumors
    • Histone Acetyl-Trasferase (HAT) inhibitors as therapeutic approach affecting lung cancer
    • Tissue engineering of the skin and mucous membraned-problems and solutions
    • Quantitative cytoskeleton analysis in 2d,ed cells exposed to microgravity and its potential impact in understanding cell regulation by means of physical constrains Role of hippo pathway in vascular didease
    • Modulation of dystrophic microenvironment to improve stem cell-mediated therapy
    • Role of micrornas in muscle biopsies and an in vitro model of myotonic dystrophy
    • The blackbox of implantation.microRNAs in spent blastocyst media as putative biomarkers of embryo reproductive competence
    • Characterization of molecular mechanism underlyng sarcopenia and sarcopenic obesity
      Unsupervised vs supervised identification of prognostic factors in rare and common types of neoplasm
    • Realization of dual mode hybrid probe for medical diagnostic
    • Mitotane treatment: effect on fertility.
      Exosomes as mediators of cross-talk between the cell population that contribute to DMD progression
    • Unravelling calcium signalling complexity during angiogenesis and melanoma progression
    • Role of HDAC4 in Amiotrophic Lateral Sclerosis (ALS) and skeletal muscle development
    • Role of phosphodiesterase 5A in Ca2+ homeostasis
    • In vitro identification of agents and mechanism responsible for the damage of the biliary tree stem cells (hBTSCs) in Primary Sclerosing Cholangitis
    • c-MET proto-oncogene in malignant testicular germ cell tumours
    • Smoke free brain: multidisciplinary tools for improving the efficacy of public prevention measures against smoking
    • Regulation of human testicular function during aging
    • A study on bone remodelling defects in nephropatic cystinosis
    • The role of c-FLIP protein in autophagy
    • Role of calreticulin and its 3'UTR in normal hematopoiesis and MPNs
    • Development of a combination startegy based on ER and oxidative stress in Acute Myeloid Leukemia
    • HIF-1 inhibition and TLR3 stimulation as combined anti-tumour treatment of apoptosis-resistant human breast cancer cells
    • Regulation of the niche factor GDNF by Retinoic Acid
    • Diffusion models to investigate tissue applications to brain and placenta development


    • c) Corsi disciplinari non mutuati (lezioni formali o seminari)

      ·      Istologia e Omeostasi dei tessuti

      ·      Embriologia, meccanismi regolativi del differenziamento

      ·      Ingegneria tissutale

      ·      Elementi di biologia, fisiologia, biochimica e biologia molecolare dell'uomo;

      ·      Tecniche di acquisizione ed analisi di biosegnali e immagini di interesse biomedico;

      ·      Tecniche di modellizzazione dinamica di biosistemi.


  • Corso di Inglese Scientifico 2017

    Corso d’inglese BEMM 2017

    Due corsi paralleli (in giorni e orari diversi per soddisfare le esigenze dei dottorandi) inizieranno lunedì 5 giugno 2017 e dureranno quindici ore ciascuno, fino a metà luglio. Ogni lezione durerà circa 75 minuti.

    I corsi si terranno presso l’Aula Monesi in Via Scarpa (dove si è svolta la valutazione preliminare). Gli studenti sono pregati di portare penna e carta.

    Per qualsiasi informazione, o richiesta di cambiare giorno di frequenza, gli studenti possono contattare il docente: lewis.baker4@gmail.com

    Corso AM: martedì e giovedi, h 9:00 - 10.15

    Corso PM: Lunedi e mercoledi, h 17:00 - 18.15

     


  • MIT-Passaggi d'anno 2016 Yearly exam

    MIT Phd course - 2016 yearly exam - October 24-25, 2016, Aula Monesi


    Cognome Nome Ciclo Curr Titolo
    Brancaccio Arianna 30 SMC Post - Translational regulation of polycomb repressive complex 2 in response to p38 signaling in muscle-derived tumors
    Cappella Marisa 30 SMC Role of microRNAs in physiology and pathology of skeletal muscle
    Cimadomo Danilo 30 STC MiRNA in human spent blastocyst media during IVF cycles. Potential biomarkers of reproductive competence
    Corano Scheri Katia 30 STC c - MET prot - oncogene in testicular germ cell tumours
    De Sanctis  Rita 30 BCT Post - relapse outcome of patients with localized retroperitoneal sarcoma treated on an Italian Sarcoma Group (ISG - STS) protocol
    Di Flumeri Gianluca 30 BCT A new EEG-based machine-learning techique to measure brain workload in operational environments
    Di Martile Marta 30 STC Histone acetyltranferase (hat) inhibitors as therapeutic approach affecting lung cancer growth and angiogenesis
    Forcina Laura 30 SMC Modulation of dystrophic microenvironment to improve stem cell mediated therapy
    Innocenti Federica 30 STC Effect of adrenocortical carcinoma treatment on fertility
    Palmerio Silvia 30 SMC Role of hippo pathway in vascular disease
    Papacci Francesca 30 STC Unravelling calcium signalling complexity during angiogenesis and tumorigenic progression
    Pigna  Eva 30 SMC Role of histone deacetylase 4 in amyotrophic lateral sclerosis and in skeletal muscle development
    Polito Claudia 30 BCT Realization of a dual mode hybrid probe for medical diagnostic
    Sandonà Martina 30 SMC Exosomes as mediators of cross - talk between the cell populations that contribute to DMD progression
    Scatozza Francesca 30 STC HIF - 1 inhibition and TLR3 stimulation as combined antitumor treatment of apoptosis  - resistant human breast cancer cells
             
    Ascenzi Francesca 31 SMC Protective role of IGF -1 against sarcopenia
    Assenza Maria Rita 31 SMC Cardiac Hypertrophy: Role of Pde5A in Ca2+ Homeostasis
    Battafarano Giulia 31 SMC A study on bone remodeling defect in Cystinosis
    Capuano Ernestina 31 SMC Sinergy of Retinoic Acid with oxidative and ER stress in Acute Myeloid Leukemia
    Castaldo Clotilde 31 SMC Positional Memory of Fibroblasts as Contributory Cause of Cell Reprogramming Low Efficiency
    Costantini  Daniele 31 SMC In vitro identification of agents and mechanisms responsible for the damage of the biliary tree stem cells (hBTSCs) in Primary Sclerosing Cholangitis
    Guerreri Michele 31 BCT The anomalous diffusion model highlights microstructural variations in brain due to aging and the biexponential model correlates with gestational age in normal human palcenta: two DWI methods to investigate biological tissues 
    Modica Enrica 31 BCT Smoke Free Brain: Evaluation of the Neuroelectrical and the Emotional Indexes for the Study of Antismoking Public Service Announcements
    Mularoni Valentina 31 STC Regulation of human steroidogenesis during aging
    Quattrocchi Alberto 31 SMC Role of calreticulin in hematopoiesis and myeloproliferative neoplasms
    Rossi Dario 31 BCT Smoke Free Brain: multidisciplinary tools for improving the efficacy of public prevention measures against smoking
    Saracino Rossana 31 STC Regulation of the spermatogonial niche factor GDNF by retinoic acid
    Tomaipitinca Luana 31 STC The role of c - FLIP protein in autophagy
    Verma Garima 31 BCT Multiscale computational modelling and quantitative analysis of cytoskeleton using novel tools and techniques




  • Scuola di dottorato BeMM

    Scuola di Dottorato in Biologia e Medicina Molecolare

    Attività didattiche della scuola BeMM: vedi https://elearning.uniroma1.it/course/view.php?id=3221


  • Tesi XXVIII Ciclo - 28th cycle PhD Theses


  • Dottorato MIT - Documenti anni precedenti

    Attraverso il link sottostante si accede all'archivio dei contenuti del sito web del Dottorato di ricerca in Morfogenesi e Ingegneria Tissutale


    Attività e documenti degli anni precedenti


  • Argomento 16